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Immunotherapy and Immune Checkpoints in Melanoma/Cancer.

  1. Sackstein R, Schatton T, Barthel SR. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017.
  2. Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, et al. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell, 162(6): 1242-56, 2015.
  3. Barthel SR, Schatton T. Homing in on the Sweet Side of Immune Checkpoint Biology. Immunity, 44(5):1083-5, 2016.


Galectins in Melanoma/Cancer, Tumor-Immunity, Inflammation, and Biomarker Development.

  1. Yazawa E, Geddes-Sweeney J, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman M, et al. Melanoma cell galectin-1 ligands functionally correlate with malignant potential. Journal of Investigative Dermatology, 135(7):1849-62, 2015
  2. Burdick MM, Reynolds NM, Martin EW, Hawes JV, Carlson GE, Cuckler CM, Bates MC, Barthel SR, and Dimitroff CJ. Isolation and characterization of chimeric human Fc-expressing proteins using protein A membrane adsorbers and a streamlined workflow. Journal of Visualized Experiments, (83):e51023, 2014.


  1. Laurent FC, Opperman M, Barthel SR, Hays D, Schatton T, et al. Metabolic inhibition of galectin-1-binding carbohydrates accentuates anti-tumor immunity. Journal of Investigative Dermatology, 132(2): 410-20, 2012.
  1. Barthel SR, Antonopoulos A, Laurent FC, Schaffer L, Hernandez G, Patil SA, et al. Peracetylated 4-fluoro-glucosamine (4-F-GlcNAc) reduces the content and repertoire of N- and O-glycans without direct incorporation. Journal of Biological Chemistry, 286(24): 21717-31, 2011.
  1. Laurent FC, Barthel SR, and Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. Journal of Immunology, 185(8): 4659-72, 2010.


Carbohydrate Adhesive Regulators of Melanoma/Cancer Metastasis.

  1. Li J, Guillebon AD, Hsu JW, Barthel SR, Dimitroff CJ, Lee YF, King MR. Human fucosyltransferase 6 enables prostate cancer metastasis to bone. British Journal of Cancer, 109(12): 3014-22, 2013.
  1. Barthel SR, Hays DL, Yazawa EM, Opperman M, Walley KC, Nimrichter L, et al. Definition of molecular determinants of prostate cancer cell bone extravasation. Cancer Research, 73(2): 942-52, 2013.
  1. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, et al. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proceedings of the National Academy of Sciences, 106(46): 19491-6, 2009.
  1. Barthel SR, Gavino JD, Wiese GK, Jaynes JM, Siddiqui J, Dimitroff CJ. Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin. Glycobiology, 18(10): 806-17, 2008.
  1. Barthel SR, Gavino JD, Descheny L, Dimitroff CJ. Targeting selectins and selectin ligands in inflammation and cancer. Expert Opinion on Therapeutic Targets, 11(11): 1-19, 2007.


Melanoma and Dermal Stem Cell Biology.

  1. Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, et al. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Reports, 12(10):1564-74, 2015.
  1. Lee N, Barthel SR, Schatton T. Melanoma Stem Cells and Metastasis: Mimicking Hematopoietic Cell Trafficking? Laboratory Investigation, 94(1): 13-30, 2013.


Adhesive and Signaling Pathways in Immune Cell Trafficking and Migration.

  1. Wiese G, Barthel SR, and Dimitroff CJ. Parallel-plate flow chamber analysis of physiologic E-selectin-mediated leukocyte rolling on microvascular endothelial cells. Journal of Visualized Experiments, Feb 11 (24), 1009, 2008.


  1. Barthel SR, Johansson MW, McNamee DM, and Mosher DF. Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. Journal of Leukocyte Biology, 83(1): 1-12, 2008.
  1. Gainers ME, Descheny L, Barthel SR, Liu L, Wurbel MA, and Dimitroff CJ. Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. Journal of Immunology, 179(12): 8509-8518, 2007.
  1. Barthel SR, Johansson MW, Annis DS, and Mosher DF. Differential engagement of modules 1 and 4 of VCAM-1 (CD106) by integrins alpha4beta1 (CD49d/29) and alphaMbeta2 (CD11b/18) of eosinophils. Journal of Biological Chemistry, 281(43): 32175-32187, 2006.
  1. Johansson MW, Barthel SR, Swenson CA, Evans MD, Jarjour NN, Mosher DF, and Busse WW. Eosinophil b1 integrin activation state correlates with asthma activity in a blinded study of inhaled corticosteroid withdrawal. Journal of Allergy and Clinical Immunology, 117(6): 1502-1504, 2006.                     11e5-8283-00000aacb35f&acdnat=1438635507_b39120f7d35c16e218b274d0218893dd
  1. Barthel SR, Johansson MW, Annis DS, Mosher DF. Cleavage of human 7-domain VCAM-1 (CD106) by thrombin. Thrombosis and Haemostasis, 95(5): 873-880, 2006.
  1. Barthel SR, Johansson MW, Jarjour NN, Mosher DF. Dissection of the hyper-adhesive phenotype of eosinophils in asthma. American Journal of Respiratory Cell and Molecular Biology, 35(3): 378-386, 2006.
  1. Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, et al. Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. American Journal of Respiratory Cell and Molecular Biology, 31: 413-422, 2004.



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